Expressions of ICAM-1,VCAM-1 and I-FABP in Lupus Enteropathy in Mice
10.3969/j.issn.1008-7125.2017.08.003
- VernacularTitle:ICAM-1、VCAM-1和I-FABP在狼疮肠病小鼠中表达的研究
- Author:
Jing HUO
;
Wen LUO
;
Mingwei LI
;
Peipei WANG
- Keywords:
Lupus Erythematosus;
Systemic;
Lupus Enteropathy;
Cell Adhesion Molecules;
Vascular Cell Adhesion Molecule-1;
Fatty Acid-Binding Proteins
- From:
Chinese Journal of Gastroenterology
2017;22(8):456-459
- CountryChina
- Language:Chinese
-
Abstract:
Background:The prognosis of systemic lupus erythematosus complicated with lupus enteropathy is poor. At present, studies on pathogenesis of lupus enteropathy are rare. Aims:To investigate the expressions of intercellular adhesion molecule-1 (ICAM-1),vascular cell adhesion molecule-1 (VCAM-1)and intestinal fatty acid binding protein (I-FABP) in lupus enteropathy in mice. Methods:Twenty MRL/ lpr lupus mice were randomly divided into two groups:lupus enteropathy group and control group. Lupus enteropathy model was established by administration with TNBS enema. Histological score was assessed,expressions of ICAM-1,VCAM-1 and I-FABP were determined by immunohistochemistry, and correlations with histological score were analyzed. Results:Compared with control group,histological score was significantly increased (8. 1 ± 5. 8 vs. 0. 8 ± 0. 5,P = 0. 000),expressions of ICAM-1 (9. 4% ± 2. 1% vs. 6. 2% ± 1. 1%),VCAM-1 (15. 1% ± 2. 1% vs. 12. 2% ± 1. 9%)and I-FABP (17. 5% ± 2. 5% vs. 6. 1% ± 0. 9%)were significantly increased (P < 0. 05)in lupus enteropathy group. Expressions of ICAM-1,VCAM-1 and I-FABP in colon tissue in lupus enteropathy group were positively correlated with histological score (r = 0. 870,P = 0. 010;r = 0. 881,P =0. 010;r = 1. 000,P = 0. 000). Conclusions:ICAM-1,VCAM-1 and I-FABP may be associated with pathogenesis of lupus enteropathy.
