Expression and Significance of CMTM3 in Helicobacter pylori Infected Chronic Gastritis
10.3969/j.issn.1008-7125.2017.05.010
- VernacularTitle:CMTM3在幽门螺杆菌感染慢性胃炎中的表达及其意义
- Author:
Shuli YANG
;
Wenling HAN
;
Hejun ZHANG
;
Yanlei GUO
;
Wanqiong YUAN
;
Wenjing WANG
;
Shigang DING
- Keywords:
Helicobacter pylori;
Gastritis;
CMTM3;
Interleukin-6;
Immunohistochemistry
- From:
Chinese Journal of Gastroenterology
2017;22(5):301-303
- CountryChina
- Language:Chinese
-
Abstract:
Background: CKLF-like MARVEL transmembrane domain containing (CMTM) superfamily is involved in the occurrence and development of inflammation, cancer and a variety of diseases.Human CMTM3 has been proposed as a putative tumor suppressor gene.Aims: To investigate the expression of CMTM3 in Helicobacter pylori (Hp) infection-related chronic gastritis and its significance.Methods: Sixty cases of outpatients with chronic gastritis (30 Hp-positive and 30 Hp-negative) were enrolled for detection of CMTM3 and interleukin-6 (IL-6) expressions in gastric mucosa by immunohistochemistry.The correlation of expressions of CMTM3 and IL-6 was analyzed.Results: The positivity rates of CMTM3 and IL-6 in gastric mucosa were significantly higher in Hp-positive chronic gastritis than in Hp-negative ones (CMTM3: 63.3% vs.30.0%, P<0.05;IL-6: 73.3% vs.13.3%, P<0.01).In patients with Hp-positive chronic gastritis, CMTM3 and IL-6 were co-expressed in 53.3% (16/30) of the patients and localized in the same position.Expression of CMTM3 was positively correlated with IL-6 expression in Hp-positive chronic gastritis patients (r=0.58, P<0.05).Conclusions: CMTM3 is highly expressed in chronic gastritis patients with Hp infection.It may participate in the occurrence and development of Hp infection-related chronic gastritis with inflammatory cytokines such as IL-6.Hp infection might be one of the mechanisms involved in CMTM3 up-regulation.
