Diagnostic Value of Serum Gastrin-17 for Antral Atrophy under Different Hp Infection Status
10.3969/j.issn.1008-7125.2017.05.006
- VernacularTitle:不同Hp感染状态下血清胃泌素-17对胃窦萎缩的诊断价值
- Author:
Chunping ZHU
;
Jianye ZHAO
;
Wei QIAN
;
Mingjun SUN
;
Wei LIU
;
Jianming XU
;
Quancai CAI
;
Yiqi DU
;
Zhaoshen LI
- Keywords:
Gastrin-17;
Helicobacter pylori;
Gastritis;
Atrophic;
Diagnosis
- From:
Chinese Journal of Gastroenterology
2017;22(5):282-286
- CountryChina
- Language:Chinese
-
Abstract:
Background: Chronic atrophic gastritis (CAG) is a precancerous lesion of gastric cancer.The diagnostic value of serum gastrin-17 (G-17) level for CAG differs substantioulsy, and Helicobacter pylori (Hp) infection may play an important role.Aims: To explore the effect of Hp infection on serum G-17 level, and the diagnostic value of serum G-17 level for CAG under different Hp infection status.Methods: A total of 204 patients with chronic non-atrophic gastritis and 81 patients with CAG from May 2014 to May 2015 at the three different hospitals were enrolled.Gastroscopy was performed, fasting serum G-17 level, postprandial serum G-17 level and Hp-IgG antibody were determined by ELISA.Results: Fasting serum G-17 level was significantly increased in Hp positive group than in Hp negative group (P=0.001), and postprandial serum G-17 level was significantly decreased in CAG group than in non-atrophy group (P=0.002).AUC of fasting serum G-17 level for diagnosing Hp positive and negative CAG were 0.634 (95% CI: 0.537-0.732) and 0.576 (95% CI: 0.478-0.675), respectively, the accuracy were 62.6% and 54.9%, respectively.AUC of postprandial serum G-17 level for diagnosing Hp positive and negative CAG were 0.675 (95% CI: 0.581-0.769) and 0.595 (95% CI: 0.495-0.694), respectively, the accuracy were 61.8% and 53.1%, respectively.Conclusions: Hp infection has impact on serum G-17 level, as a result, the diagnostic value of G-17 level for CAG is different for patients with and without Hp infection.Diagnostic values of fast and postprandial serum G-17 for Hp positive CAG are higher than Hp negative CAG.
