Exenatide Weaks Tumor Angiogenesis within Endometrial Cancer Ishikawa Xenografts in Nude Mice
- VernacularTitle:艾塞那肽抑制子宫内膜癌Ishikawa细胞株裸鼠移植瘤的血管生成
- Author:
Yu ZHANG
;
Juan CHENG
;
Fen XU
- Keywords:
exenatide;
endometrial cancer;
Ishikawa;
angiogenesis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2017;38(3):327-331
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the role of exenatide on angiogenesis in endometrial cancer Ishikawa xenografts in nude mice.[Method] We used the subcutaneous human endometrial cancer cell Ishikawa xenografts in nude mice model,and divided them into control group and exenatide-treated group.The harvested tumors were preserved for immunohistochemistry staining and western blot analysis.[Results] The micro-vessel density (CD31 positive) in exenatide-treated group was (13.2 ± 1.4)/400 power field,less than that in control group [(25.9 ± 5.8)/400 power field] (P ＜ 0.01).The expression level of VEGF was significantly lower in exenatide-treated group than that in control group (P ＜ 0.05).The mean density of tumor associated macrophages (F4/80 positive) is (31.4 ± 3.4)％ in exenatide-treated group and (72.1 ± 4.2)％ in control group with significant difference (P ＜ 0.01).[Conclusion] Exenatide weaks tumor angiogenesis within endometrial cancer Ishikawa xenografts in nude mice.
