Comparative study of neurological soft signs in remittent schizophrenia and non-psychotic first-degree relatives
10.3969/j.issn.1002-0152.2017.02.005
- VernacularTitle:缓解期精神分裂症患者及其一级非患病亲属神经系统软体征比较研究
- Author:
Yingying FENG
;
Xiaohua HU
;
Yan TIAN
;
Yun JIANG
;
Zongqin WANG
;
Zuohui GAO
;
Ling BAO
- Keywords:
Schizophrenia;
Remission;
Neurological soft signs;
First degree relatives;
Endophenotype
- From:
Chinese Journal of Nervous and Mental Diseases
2017;43(2):85-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the difference of neurological soft signs (NSS) among the remittent schizophrenia patients,first-degree non-psychotic relatives of schizophrenia patients and healthy controls.Methods The Cambridge Neurological Inventory (CNI) (the Chinese version) was administered to 86 remittent schizophrenia patients (patient group),86 first-degree non-psychotic relatives of schizophrenia patients (relative group) and 86 healthy controls (control group).Results Compared with relative group,NSS total-score,the subscore of motor coordination and sensory integration were significantly higher in patient group (P＜0.01).Compared with control group,NSS total-score,the subscore of motor coordination and sensory integration were significantly higher in patient group (P＜0.01).Compared with control group,NSS total-score and the subscore of motor coordination were significantly higher in relative group (P＜0.01).Conclusions The levels of NSS in remittent schizophrenia patients and their first-degree non-psychotic relatives are higher than normal control,and the patients have more NSS than their relatives.The motor coordination nay be a potential endophenotype for schizophrenia.
