High resolution MR T2WI combined with DWI in evaluation of pathological complete response after neoadjuvant therapy in rectal cancer
10.13929/j.1672-8475.201612020
- VernacularTitle:高分辨率MR T2WI联合DWI评价直肠癌新辅助治疗后病理学完全缓解
- Author:
Xiaoyan ZHANG
;
Xiaoting LI
;
Yanjie SHI
;
Zhilong WANG
;
Yuliang LIU
;
Haibin ZHU
;
Yingshi SUN
- Keywords:
Diffusion magnetic resonance imaging;
Rectal neoplasms;
Pathology;
Complete response
- From:
Chinese Journal of Interventional Imaging and Therapy
2017;14(3):164-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of high resolution MR T2WI combined with DWI in evaluation of pathological complete response after neoadjuvant therapy in rectal cancer.Methods Totally 364 patients with locally advanced rectal cancer who recieved neoadjuvant therapy and radical surgery,underwent MR scanning before and after neoadjuvant therapy,were enrolled in this study.The diagnostic efficacy of high resolution MR T2WI and high resolution MR T2WI combined with DWI in evaluation on pathological complete response after neoadjuvant therapy in rectal cancer were compared.Results Finally 49 cases were demonstrated pathologic complete response.Accuracy,sensitivity,specificity,positive predictive value and negative predictive value of high resolution MR T2WI and high resolution MR T2WI combined with DWI in predicting on pathological complete response after neoadjuvant therapy were 82.69％ (301/364),40.82％ (20/49),89.21％ (281/315),37.04％ (20/54),90.65％ (281/310)and 87.36％ (318/364),65.31％ (32/49),90.79％ (286/315),52.46％ (32/61),94.39％ (286/303),respectively.Sensitivity had statiatical significant difference between two methods (x2 =4.96,P=0.03).Conclusion Compared with high-resolution T2WI,the combination of DWI and high-resolution T2WI can improve the diagnostic efficacy in evaluation of pathologic complete response of locally advanced rectal cancer.
