Correlation study on glycated albumin to HbA1C ratio and amplitude of glucose excursions in new-onset fulminant type 1 diabetes

VernacularTitle:新发暴发型1型糖尿病中糖化白蛋白/HbA1C比值与血糖波动幅度的相关性研究
Author: Bairong WANG ; Zhiqiang LU ; Xiaomu LI ; Xin GAO
Keywords: Diabetes mellitus; type 1; Fulminant type 1 diabetes; Glycated albumin; HbA1C
From: Chinese Journal of Endocrinology and Metabolism 2017;33(4):326-329
CountryChina
Language:Chinese
Abstract: Thirty-three patients with new-onset type 1 diabetes from Zhongshan Hospital, Fudan University were recruited from 2013 to 2014. Relevant clinical data were collected for the statistical analysis. Among the 33 patients with type 1 diabetes, there were 7 with fulminant type 1 diabetes (FT1DM), 12 acute onset type 1 diabetes (AT1DM), and 14 with slowly progressive type 1 diabetes (SPIDDM). The fasting and stimulated C-peptide levels were significantly lower while glycated albumin (GA)/HbA1C and mean amplitude of glucose excursions (MAGE) levels were significantly higher in FT1DM group compared with other two groups(all P<0.05). Pearson correlation analysis in all patients with type 1 diabetes revealed that GA/HbA1C was correlated with fasting C-peptide, MAGE, and difference of the peak blood glucose to the lowest blood glucose (ΔBG) levels (all P<0.05). Stepwise multivariate analysis showed that GA/HbA1C was independently correlated with MAGE and ΔBG (P<0.05). Logistic regression model indicated that GA, HbA1C, and GA/HbA1C were independently correlated with FT1DM.