The expression and prognostic significance of Fibulin-5 in gastric carcinoma
10.3760/cma.j.issn.1007-631X.2017.03.018
- VernacularTitle:胃癌组织中Fibulin-5的表达及其与患者预后的关系
- Author:
Chaogang YANG
;
Xiaohua LENG
;
Jinxuan HOU
;
Bin XIONG
- Keywords:
Stomach neoplasms;
Prognosis;
Pathology;
clinical;
Fibulin-5
- From:
Chinese Journal of General Surgery
2017;32(3):247-250
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of Fibulin-5 in gastric cancer and its correlation with the prognosis of gastric cancer.Methods Tissue chips from 90 gastric cancer cases were used to study the expression of Fibulin-5 protein in cancer tissue and para-carcinoma tissue by immunohistochemistry,and analyze the correlation of Fibulin-5 expression and clinical pathological characteristics.Results The expression of Fibulin-5 in gastric cancer tissue was higher than that of para-carcinoma tissue [cytoplasm:(6.2±4.2) vs.(5.1 ±3.7);nucleus:(7.2 ±3.8) vs.(4.9 ±2.5),all P＜0.05],which was positively related with patient's age (r =0.213,P =0.044) in the cytoplasm of cancerous tissue.The expression of Fibulin-5 in the cytoplasm of cancerous tissue was negatively related with patient's overall survival (25％ vs.56％,P =0.027),which was an independent predictor (P =0.037).Conclusion Fibulin-5 is an independent prognostic factor of gastric cancer,its expression might be related with shortend patient's survival time.
