Diagnostic Value of APRI Combined With FIB-4 for Significant Liver Fibrosis in Patients With Chronic Hepatitis B
10.3969/j.issn.1008-7125.2017.09.007
- VernacularTitle:APRI、FIB-4联合对慢性乙型肝炎患者显著肝纤维化的诊断价值
- Author:
Xiaohui MA
;
Xin ZHANG
;
Yun YOU
;
Lili JIANG
;
Jin ZHAO
;
Zhanguo NIE
- Keywords:
APRI;
FIB-4;
Hepatitis B,Chronic;
Liver Cirrhosis;
Diagnosis
- From:
Chinese Journal of Gastroenterology
2017;22(9):544-547
- CountryChina
- Language:Chinese
-
Abstract:
Background:The diagnostic accuracy of APRI and FIB-4 for liver fibrosis in patients with chronic hepatitis B is nothigh,especially for significant liver fibrosis (F≥2). Noninvasive diagnosis for liver fibrosis has become a research hotspot;and the diagnostic value of APRI combined with FIB-4 is not clear. Aims:To investigate the diagnostic value ofAPRI combined with FIB-4 for significant liver fibrosis in patients with chronic hepatitis B. Methods:A total of 171patients with chronic hepatitis B from January 2011 to October 2016 at General Hospital of Xinjiang Military Region wereenrolled. Liver biochemical indices,routine blood test and liver biopsy pathology were performed. APRI and FIB-4 werecalculated,ROC curve was drawn,and cutoff value of APRI and FIB-4 for diagnosing significant liver fibrosis wasdetermined,and mode of APRI combined with FIB-4 for diagnosing significant liver fibrosis was established. Results:Withthe increase in degree of liver fibrosis,APRI and FIB-4 were gradually increased (P < 0. 05). Area under ROC curve(AUC)for APRI and FIB-4 were 0. 812 and 0. 770,respectively. The sensitivity of FIB-4 for diagnosing significant liverfibrosis was higher than that of APRI. Sensitivity,specificity,negative predictive value,positive predictive value,andaccuracy of APRI combined with FIB-4 for diagnosing significant liver fibrosis were superior to APRI or FIB-4 used alone;and the specificity,accuracy of mode 2 were superior to mode 1. Conclusions:APRI combined with FIB-4 can increasethe accuracy for diagnosing significant liver fibrosis.
