Correlation between Preoperative Plasma Fibrinogen Level and Chemotherapy Effect in Ovarian Cancer Patients
10.3969/j.issn.1008-049X.2017.09.018
- VernacularTitle:卵巢癌术前血浆纤维蛋白原水平与化疗效应的相关性研究
- Author:
Keyu XIE
;
Xianfeng XIE
- Keywords:
Fibrinogen;
Ovarian cancer;
Chemotherapy effect
- From:
China Pharmacist
2017;20(9):1593-1595
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between fibrinogen levels and chemotherapy effect of platinum drugs in ovarian cancer patients. Methods:Totally 91 ovarian cancer patients and 95 patients with benign ovarian tumor were involved in our retrospec-tive study, and the associations between preoperative fibrinogen levels and clinic pathologic parameters in the patients were analyzed. Results:High fibrinogen levels were observed in 36.26％ (33/91) of the patients with ovarian cancer ( >4.0 g·L-1), which was significantly higher than that in the patients with benign tumor(P<0. 05). The high fibrinogen levels in ovarian cancer patients were associated with the higher FIGO stage and poor chemo-response, while were not associated with the patients' age, CA-125 levels and histological type and grade (P>0. 05). More importantly, no correlation was observed between high blood fibrinogen and CA-125 lev-els (P>0.05). Chemotherapy resistance was more in the patients with high fibrinogen levels than that in the other patients(P <0. 05). The OR value of high fibrinogen levels was 3. 571, 95％ CI was 1. 276-10. 000, which suggested high fibrinogen level is a dangerous factor for chemotherapy resistance. Conclusion:The study suggested that elevated fibrinogen level was a dangerous factor for chemotherapy response, which has a potential role in the poor prognosis of ovarian cancer patients independent of CA-125.
