Correlation between 1H-MRS and the expression of VEGF,MMP-9 and uPA in brain glioma
10.3969/j.issn.1002-1671.2017.09.002
- VernacularTitle:脑胶质瘤1H-MRS的应用与VEGF、MMP-9及uPA表达的相关性研究
- Author:
Jia WANG
;
Hua FENG
;
Yi LIANG
;
Zhen LI
;
Bolin DU
;
Haibo XU
- Keywords:
brain glioma;
magnetic resonance spectroscopy;
VEGF;
MMP-9;
uPA
- From:
Journal of Practical Radiology
2017;33(9):1333-1336
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between 1H-MRS features of brain glioma and its pathological grade and invasiveness, and the correlation between those features and the expression of VEGF, MMP-9 and uPA.Methods The brain gliomas in 55 patients confirmed by pathology were divided into two groups: high grade and low one.An analysis of intragroup and intergroup differences in some metabolite ratios of 1H-MRS in the tumor parenchyma was conducted.The expression of MMP-9,VEGF and uPA in brain glioma was detected,and the correlation between the above three parameters and changes in metabolite ratios of 1H-MRS were explored.Results There was significant difference and correlation in Cho/Cr and Cho/NAA ratio in the tumor parenchyma between high and low grade(P<0.01).The expression of VEGF and MMP-9 in tumor was significantly different(P<0.01) but with significant correlation(P<0.01),and there was no significant difference and correlation in NAA/Cr ratio and uPA expression(P>0.05).Conclusion VEGF and MMP-9 play an important role in the development of brain glioma.Cho/Cr and Cho/NAA ratios provide an important reference for preoperative grading of brain gliomas and indirectly reflect the expression of VEGF and MMP-9.
