Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study.
10.3346/jkms.2014.29.5.743
- Author:
Sun Seog KWEON
1
;
Young Hoon LEE
;
Seul Ki JEONG
;
Hae Sung NAM
;
Kyeong Soo PARK
;
Seong Woo CHOI
;
Bok Hee KIM
;
Hee Nam KIM
;
Jin Su CHOI
;
Min Ho SHIN
Author Information
1. Department of Preventive Medicine, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju, Korea. mhshinx@paran.com
- Publication Type:Brief Communication
- Keywords:
Homocysteine;
Folic Acid;
Reference Intervals;
Aged Population
- MeSH:
Age Factors;
Aged;
Aging;
Cohort Studies;
Female;
Folic Acid/*blood;
Genotype;
Homocysteine/*blood;
Humans;
Male;
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics;
Middle Aged;
Reference Values;
Republic of Korea;
Sex Factors
- From:Journal of Korean Medical Science
2014;29(5):743-747
- CountryRepublic of Korea
- Language:English
-
Abstract:
The reference interval for plasma total homocysteine (tHcy) and serum folate concentrations were estimated. Total of 3,154 reference individuals (1,029 men and 2,125 women) were selected based on stringent exclusion criteria. For plasma tHcy concentration (microM/L), reference values (median [5-95 percentile]) were 7.72 (5.03 to 13.80) and 6.09 (3.95-10.19) in men and women, respectively. For serum folate concentration (nM/L), reference values were 23.71 (11.73-38.44) and 28.95 (15.23-40.44) in men and women, respectively. The tHcy levels of both genders in the present study were lower than those in previous reports from other countries and Korea.
