Expression and Clinicopathological Significance of N-cadherin in the Ovarian Carcinoma
10.13241/j.cnki.pmb.2017.22.039
- VernacularTitle:N-cadherin在卵巢癌中的表达及其临床病理意义
- Author:
Shuhong YU
;
Tong YANG
;
Qian FENG
;
Ru ZHOU
;
Yingmei WANG
;
Jing ZHANG
- Keywords:
Ovarian carcinoma;
N-cadherin;
Immunohistochemistry;
Clinicopathological features
- From:
Progress in Modern Biomedicine
2017;17(22):4361-4364
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression of N-cadherin and its correlations with the clinicopathological features of human ovarian carcinoma.Methods:The expression of N-cadherin in 281 cases of ovarian carcinoma tissues were determined by immunohistochemical method.The correlations of N-cadherin expression with the clinicopathological features of human ovarian carcinoma were analyzed.Results:There was higher expression of N-cadherin in the metastatic lesions than its paired primary lesions (P =0.018).The expression level of N-cadherin in ovarian carcinoma was correlated with the FIGO stage (P =0.034),histological type (P ＜0.001) and tumor grade (P =0.004).Conclusions:High expression of N-cadherin might positively correlate with the invasion and migration ability of ovarian carcinoma cells,which was more common in the the advanced (FIGO Ⅱ-Ⅳ) ovarian carcinoma,high-grade serous carcinoma,and high grade ovarian carcinoma.N-cadherin might be useful in estimating the biological behavior of human ovarian carcinoma.
