Role of type II innate lymphoid cells in browning of white adipose tissue
10.3969/j.issn.1000-4718.2017.02.029
- VernacularTitle:II 型固有淋巴细胞在白色脂肪棕色化中的作用
- Author:
Jun SUN
;
Chaobo LIU
;
Xiuhe PAN
;
Wenwen JIANG
;
Mingcai LI
;
Yan LI
- Keywords:
Type II innate lymphoid cells;
White adipose tissue;
Brown adipose tissue;
Beige adipose tis-sue;
White adipose tissue browning;
Interleukin-33
- From:
Chinese Journal of Pathophysiology
2017;33(2):365-368,374
- CountryChina
- Language:Chinese
-
Abstract:
Type II innate lymphoid cells ( ILC2s) are widely distributed in the blood , intestines, trachea, lung, spleen, liver, animal fat and skin, and involved in the innate immune responses .ILC2s have attracted much atten-tion for its important roles in the conversion of white adipose to beige adipose .Studies have shown that ILC2s are essential for the proliferation and differentiation of adipocyte precursor cells , and they also play a vital role in anti-parasitic infection and allergic inflammation .This review discusses the discovery , differentiation , development , distribution and function of ILC2s, and their relationships with the browning of white adipose tissue for providing valuable references on understanding the pathogenesis , prevention and treatment of obesity and fat metabolism disorders .
