Clinical Observation of Carbamazepine Combined with Topiramate in the Treatment of Partial Epilepsy
10.6039/j.issn.1001-0408.2015.30.13
- VernacularTitle:卡马西平联合托吡酯治疗部分性癫痫的临床观察
- Author:
Yunbo LUO
;
Silu PENG
;
Xuejie XU
;
Xingjiang TANG
- Publication Type:Journal Article
- Keywords:
Carbamazepine;
Topiramate;
Partial epilepsy;
Seizure frequency
- From:
China Pharmacy
2015;(30):4213-4214,4215
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of carbamazepine combined with topiramate in the treatment of par-tial epilepsy. METHODS:130 patients with partial epilepsy were randomly divided into observation group and control group. Con-trol group was orally treaed with carbamazepine 100 mg,3 times a day. Based on the treatment of control group,observation group was orally treaed with topiramate initial dose of 25 mg,once a day,and then increased 25 mg every week,the maximum dose was no more than 200 mg,once a day. After 6 months,the efficacy was evaluated,frequency of epileptic seizures,EEG epileptiform discharges wave and incidence of adverse reactions were observed. RESULTS:The total effective rate in observation group was sig-nificantly higher than control group(P<0.05). After treatment,the frequencies of epileptic seizures in 2 groups were significantly lower than before,6 months<3 months<1 month,and observation group was lower than control group(P<0.05).The EEG epilep-tiform discharges wave were in observation significantly better than control group(P<0.05). There were no significant differences incidence of adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Carbamazepine combined with topiramate has better efficacy than carbamazepine alone in the treatment of partial epilepsy,with similar safety.
