Role of platelet-derived growth factor after hemorrhagic shock in rats
10.11659/jjssx.06E014128
- VernacularTitle:血小板衍生生长因子对失血性休克大鼠器官功能的保护作用
- Author:
Dan LAN
;
Yu ZHU
;
Xiaoyong PENG
;
Liangming LIU
;
Tao LI
- Publication Type:Journal Article
- Keywords:
platelet-derived growth factor;
survival rate;
blood flow of liver and kindy;
mitochondrial respiration control ration
- From:
Journal of Regional Anatomy and Operative Surgery
2015;(2):166-168,169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate platelet-derived growth factor ( PDGF ) protection on blood flow and mitochondrial function of hemorrhagic shock rats. Methods Ninety-six SD rats were randomly divided into six groups including shock group, lactated ringer's solution (LR) resuscitation group,PDGF treatment groups(1,3. 5,7,15μg/kg). Laster-Doppler and oxygen concentration determination method were applied to observe the protective effect of PDGF treatment on animal survival,blood flow and mitochondrial function in liver and kidney. Re-sults As compared with LR resuscitation group,PDGF treatment increased animal survival rate and also improved blood fiow of liver and kindy,mitochondrial respiration control ration(RCR),of which the group with 3. 5μg/kg had the best result. Conclusion This finding sug-gests that PDGF may be a potential agent to treat acute critical such as hemorrhagic shock.
