Relationship between serum 25-hydroxy vitamin D3 concentration and community-acquired pneumonia in infants
10.3760/cma.j.issn.1008-6706.2016.04.009
- VernacularTitle:25-羟维生素 D3水平与婴幼儿社区获得性肺炎的关系
- Author:
Huisu FAN
;
Jie WU
;
Chunsheng QU
;
Huizhu LI
;
Houxing LEI
;
Zhiwei GAO
;
Jianfei LYU
;
Jianjun LIN
;
Yong XU
;
Wenfen LEI
;
Xiucong LAN
- Publication Type:Journal Article
- Keywords:
Community-acquired pneumonia(CAP);
Severe pneumonia;
25-(OH)D3;
IgA;
Alka-line phosphatase
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;(4):512-515,516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship and clinical significance between the concentration of 25-hydroxy vitamin D3 [25-(OH)D3 ]in the serum and community-acquired pneumonia(CAP)in infants.Methods The study recruited 98 infants.There were 68 cases of mild pneumonia and 30 cases of severe pneumonia.The con-centration of 25-(OH)D3 in serum,IgA and alkaline phosphatase(AKP)were measured.33 infants who accepted physical examination in the outpatient department were selected as control group at the same time.Results The serum 25-(OH)D3 concentration of severe pneumonia was (21.09 ±7.32)ng/mL,mild pneumonia was (25.77 ± 8.06)ng/mL and the control group was (37.13 ±6.94)ng/mL.The differences among the three groups had statisti-cally significant differences(t =9.18,3.72,5.34,all P <0.05).The differences of serum IgA concentration among the three groups had statistically significant differences (t =5.42,3.96,8.92,all P <0.05).But serum AKP concen-tration among the three groups had no statistically significant differences(t =0.86,0.58,0.47,all P >0.05).The prevalence of Vitamin D deficiency was 40.0%,which was higher than mild pneumonia patients(20.6%)and the healthy children(9.1%)(χ2 =8.43,17.55,all P <0.05).Conclusion The serum 25-(OH)D3 concentration and IgA of CAP patients were lower than healthy children,especially in severe pneumonia cases.The prevalence of Vita-min D deficiency was significantly higher than healthy children.There were no relevance between the serum concentra-tion of 25-(OH)D3 ,IgA and AKP.25-(OH)D3 plays an important role in the development of CAP.The low level of serum 25-(OH)D3 concentration may be one of the risk factors and has correlation to the severity of pneumonia.
