The value of interleukin 35 in assessing the prognosis of severe hepatitis

VernacularTitle:白细胞介素35对重型肝炎预后预测价值的研究
Author: Yong DENG ; Jie YANG ; Zheng DENG ; Shuqiang OU ; Zihui QIU ; Shuigen HUANG ; Yu CHEN
Publication Type:Journal Article
Keywords: Severe hepatitis; Interleukin -35
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(10):1470-1472,1473
CountryChina
Language:Chinese
Abstract: Objective To explore the significance of interleukin -35 (IL -35)in serum of patients with severe hepatitis.Methods Collected 39 cases of chronic hepatitis B(CHB)patients and severe hepatitis,and col-lected 19 cases of healthy control's(HC)peripheral blood at the same time.ELISA method was used to detect IL -35 levels.Results IL -35 in CHB and severe hepatitis group [(483.5 ±280.7)ng/mL and (277.9 ±248.7)ng/mL] were higher than HC group (50.5 ±47.8)ng/mL(t =2.089,3.303,P =0.044,0.002).In severe hepatitis group, the IL -35 levels in survivors group (305.3 ±301.2)ng/mL was higher than death group (78.7 ±33.2)ng/mL (P =0.012).IL -35 was positively correlated with ALT and AST,the correlation coefficient were 0.649 and 0.599. Conclusion IL -35 is involved in the pathogenesis of hepatitis B process,the low serum IL -35 levels in severe hepatitis patients may herald a bad prognosis.