Primary central nervous system histiocytic sarcoma：one case report and literature review

VernacularTitle:原发中枢神经系统组织细胞肉瘤一例并文献复习
Author: Haifeng ZHANG ; Jiwei BAI ; Guang LI
Publication Type:Journal Article
Keywords: Central nervous system neoplasms; Histiocytic sarcoma; Pathology
From: Journal of Leukemia & Lymphoma 2016;25(3):178-180,185
CountryChina
Language:Chinese
Abstract: Objective To investigate the diagnostic criteria, clinical management and prognostic factors of primary central nervous system (CNS) histiocytic sarcoma (HS). Methods An adult patients with primary CNS HS was reported, and literature on the rare entity were reviewed. Results The patient had no previous history of disease. Magnetic resonance imaging (including magnetic resonance spectroscopy) suggested a mass in the frontal lobe with obvious vasogenic edema, which was considered glioma. Surgery was the initial treatment and the tumor was totally removed. The histological findings revealed the HS. The patient received concomitant chemoradiotherapy postoperatively and currently lived without recurrence. Conclusions Primary CNS HS is extremely rare hematopoietic malignant tumor. The pathological feature and comprehensive immunophenotype panel are the useful ways to establish the diagnosis till now. Primary CNS HS should be treated intensively with surgery, chemotherapy, and/or radiation therapy. However, prognosis is disappointed in most of patients. Concomitant chemoradiotherapy might be an alternative treatment.