Neuroprotection and mechanisms of dexmedetomidine
10.3969/j.issn.1001-1978.2015.11.004
- VernacularTitle:右美托咪定的神经保护作用及其相关机制
- Author:
Lijiao CHEN
;
Qingsheng XUE
;
Buwei YU
- Publication Type:Journal Article
- Keywords:
dexmedetomidine;
α2-adrenoreceptor agonist;
neu-roprotection;
cognitive function;
sedation;
anesthesia
- From:
Chinese Pharmacological Bulletin
2015;(11):1493-1495,1496
- CountryChina
- Language:Chinese
-
Abstract:
Dexmedetomidine( DEX) is a pure potent, highly se-lective and highly specific agonist ofα2-adrenergic receptors with sedative, analgesic and sympatholytic properties. The sedative effect mimics natural sleep of“arousable” and“cooperative” se-dation without respiratory depression. Due to the above properties and advantages, DEX has received adequate attention in clinical practice and its spectrum of application is also expanding. In re-cent years, it is proved that DEX is neuroprotective not only in animal researches but also in clinical studies. The neuroprotec-tion of DEX and its related mechanism will be briefly reviewed in this paper.
