Advances in studies on role of Nesfatin-1 in depression
10.3969/j.issn.1001-1978.2015.08.003
- VernacularTitle:Nesfatin-1在抑郁症发病中的作用研究进展
- Author:
Yayun XU
;
Jinfang GE
;
Feihu CHEN
- Publication Type:Journal Article
- Keywords:
Nesfatin-1;
feeding behavior;
stress;
hypothalamic-pituitary-adrenal axis;
depression;
anhedonia;
insulin signaling
- From:
Chinese Pharmacological Bulletin
2015;(8):1044-1047,1048
- CountryChina
- Language:Chinese
-
Abstract:
Nesfatin-1, discovered in 2006 by Oh-I as an 82-ami-no-acid peptide derived from the precursor protein nucleobindin2 (NUCB2), has been identified to play an important role in the regulation of food intake and energy metabolism. Recently, it has also been found that Nesfatin-1 might be associated with the pathogenesis of depression. This article reviewed the advances in related studies on Nesfatin-1 at home and abroad, which should throw light in expliciting the physiological function of Nesfatin-1 and understanding the neurobiological mechanism of depression.
