Function and correlation of follicular helper T cells and B cells in alcohol abuse non-traumatic osteonecrosis of femoral head
10.3969/j.issn.1000-484X.2015.08.025
- VernacularTitle:外周血滤泡辅助性T细胞与B细胞在酒精性股骨头坏死患者中的作用
- Author:
Fupeng DING
;
Changlin QI
;
Hui GAO
;
Yijun LIU
;
Jing WANG
;
Yuxing SHAN
- Publication Type:Journal Article
- Keywords:
Alcohol abuse Non-traumatic Osteonecrosis of the Femoral Head;
Follicular helper T( Tfh) cell;
B cell;
IL-21
- From:
Chinese Journal of Immunology
2015;(8):1109-1112,1119
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the roles of follicular helper T(Tfh)cells,serum IL-21 and B cells in the pathogenesis of alcohol abuse non-traumatic osteonecrosis of the femoral head ( NONFH ) .Flow cytometry was used to measure the frequencies of peripheral blood inducible Tfh cells and B cells in alcohol abuse NONFH patients and healthy controls.The disease progression and the extent of femoral head collapse,the serum IL-21 were quantified.Methods: A significantly higher percentages of CD19+B cells(t=3.765,P=0.0005),CD86+CD19+B cells(t=5.506,P<0.0001),and CD95+CD19+B cells(t=4.152,P=0.0002) in patients than those in controls was found.The percentages of CD86+CD19+B cells were positively associated with the index of femoral head collapse in alcohol abuse NONFH(P<0.0001,r=0.536).Results: The frequencies of Tfh cells (t=7.611,P<0.0001),and IL-21+Tfh cells (t=5.281,P<0.0001) were higher than those in controls;The frequencies of Tfh cells were positively associated with the percentages of CD19+B cells(P=0.0002,r=0.455),IL-21+Tfh cells were positively associated with the percentages of CD86+CD19+B cells(P=0.0002,r=0.447).Conclusion: Tfh cells and B cells may participate in the pathogenesis of alcohol abuse NONFH,and increased CD86+CD19+B cells may be associated with the extent of femoral head collapse,the interaction of Tfh cells and B cells may have an im-portant role in pathogenesis of alcohol abuse NONFH.
