Study on the expression of aromatase P450, COX-2, ER and PR in adenomysis
10.3760/cma.j.issn.1008-6706.2015.03.003
- VernacularTitle:子宫腺肌病患者芳香化酶P450、环氧合酶2及雌、孕激素受体表达的研究
- Author:
Ping CHENG
;
Yanqin JI
;
Minghui ZHOU
;
Huifen LIU
- Publication Type:Journal Article
- Keywords:
Adenomysis;
Aromatase P450;
Cycloxygenase-2;
Estrogen receptor;
Progesterone receptor
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;22(3):326-329,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of aromatase P450,COX-2,ER and PR in the patients with adenomysis.Methods The immunohistochemistry staining was used to detect the expression of aromatase P450,COX-2,ER and PR in ectopic endometrium and eutopic endometrium of 30 patients with adenomyosis and 30 cases in control group.Results The expression of aromatase P450,COX-2 in ectopic endometrium were significantly higher than those in eutopic endometrium (all P ＜ 0.05) ; The expression of ER,PR in ectopic endometrium were significantly lower than those in eutopic endometrium (all P ＜ 0.05),excepted the expression of PR in eutopic endometrium,the expressions of both ER and PR lose their periodical cycle.There was positive correlation between the expression of aromatase P450 and COX-2 in adenomysis group(P ＜ 0.05).In adenomyosis,the expression of aromatase P450,COX-2,ER and PR in dysmenorrhea subgroup were significantly higher than those in non-dys menorrhea subgroup(all P ＜ 0.05).Conclusion Aromatase P450,COX-2 and ER play important roles in the genesis and development of adenomyosis and dysmenorrheal,PR is not the main pathogenic factors of adenomyosis.The expressions of aromatase P450,COX-2 and ER in adenomyosis have nothing to do with endometrial cyclical change and are not subject to the regulation of ovarian hormones.
