Prenatal Diagnosis of Transient Abnormal Myelopoiesis in a Down Syndrome Fetus.
10.3348/kjr.2009.10.2.190
- Author:
Gwang Jun KIM
1
;
Eun Sil LEE
Author Information
1. Department of Obstetric and Gynecology, Chung-Ang University School of Medicine, Seoul, Korea. les740822@yahoo.co.kr
- Publication Type:Case Report
- Keywords:
Transient abnormal myelopoiesis;
Hepatosplenomegaly;
Ventriculomegaly;
Down syndrome
- MeSH:
Adult;
Down Syndrome/*ultrasonography;
Female;
Fetal Blood/cytology;
Fetal Death;
Fetal Diseases/*diagnosis;
Hepatomegaly/ultrasonography;
Humans;
Leukocytosis/diagnosis;
*Myelopoiesis;
Pregnancy;
*Prenatal Diagnosis;
Splenomegaly/ultrasonography;
Thrombocytopenia/diagnosis
- From:Korean Journal of Radiology
2009;10(2):190-193
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of transient abnormal myelopoiesis in a Down syndrome fetus diagnosed at 28(+3) weeks of gestation that rapidly progressed to intrauterine death 10 days later. Fetal hepatosplenomegaly with cerebral ventriculomegaly, although not specific, may be a suggestive finding of Down syndrome with transient abnormal myelopoiesis. Prompt fetal blood sampling for liver function test and chromosomal analysis are mandatory for early detection and management.
