Study of MRI findings and clinicopathological characteristics of DPT (report of 5 cases and literature review)

VernacularTitle:脑脱髓鞘假瘤MR I与临床病理特征分析（5例报告并文献复习）
Author: Xibin WANG ; Bo WANG ; Meng WANG ; Chao YANG ; Xiaolong HE ; Xue ZHAO
Publication Type:Journal Article
Keywords: demyelinating pseudotumor; magnetic resonance imaging; pathology
From: Journal of Practical Radiology 2014;(10):1631-1633,1637
CountryChina
Language:Chinese
Abstract: Objective To explore the characteristics of MRI images and pathological features of demyelinating pseudotumor (DPT).Methods Five patients with demyelinating pseudotumor were histologically confirmed.Their MR imaging were re-viewed and the enhancement patterns were analyzed.Results Among the five cases with demyelinating pseudotumor,single le-sion was found in 4 cases,and multiple lesions in 1 case.Most lesions had a clear boundary and these space occupying lesions were irregular (3 cases).The signal intensity on T1 WI was lower than edema,and it had a specific “core and halo”feature,du-al-high signal with different intensity on T2 WI,slightly higher signal intensity on DWI,and on enhanced MRI,nodular or patch-y enhancement and open ring enhancement with edema around the lesions were observed.The pathological results showed that the demyelination occurred but the neuraxon survived,lymphocytes were infiltrated,glial cells were proliferated,megakaryo-cytes also could be found,and multiple monocyte-macrophages were all around the lesions.Conclusion The MRI of DPT has some characteristic features.