Difference of CD3+CD4+and CD3+CD8+T cells between patients with advanced small cell lung cancer and non-small cell lung cancer
10.3969/j.issn.1000-484X.2015.01.024
- VernacularTitle:小细胞和非小细胞肺癌晚期患者 CD3＋CD4＋及CD3＋CD8＋T淋巴细胞亚群的差异
- Author:
Shanshan WU
;
Feng YAN
;
Yuling DENG
;
Lamei YU
- Publication Type:Journal Article
- Keywords:
Small cell lung cancer;
Non-small cell lung cancer;
Advanced lung cancer;
CD4+T cells;
CD8+T cells;
NSCLC;
SCLC
- From:
Chinese Journal of Immunology
2015;(1):114-116,121
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the difference of CD3+CD4+and CD3+CD8+T cells between patients with advanced small cell lung cancer and with non-small cell lung cancer, and provide available reference for treatment.Methods: Peripheral blood was taken from 65 patients with advanced lung cancer which was included 14 cases of small cell lung cancer and 51 cases of non-small cell lung cancer, 20 cases normal controls.The expression of CD3+CD4+ and CD3+CD8+ on lymphocytes was analyzed with flow cytometry.Results:We found that the percentage of CD3+CD4+T cells in small cell and non-small cell lung cancer patients were both much less than that of normal controls.There was no significant variation in the percentage of CD3+CD8+T cells between advanced lung cancer patients and normal controls.CD4+/CD8+in patients with advanced small cell lung cancer were a lot less than those in normal controls.Conclusion:Both of the percentage of CD3+CD4+T cells in small cell and non-small cell advanced lung cancer patients were significantly decreased than that in normal controls.Patients who attacked with advanced lung cancer were severely injured in cellular immunity.
