Expressions of LYVE-1 and PROX-1 in Breast Carcinoma and Their Clinical Significance
10.3870/j.issn.1672-0741.2014.04.014
- VernacularTitle:乳腺癌组织中LYVE-1和PROX-1的表达及临床意义
- Author:
Juncheng WEI
;
Danfeng LUO
;
Ding MA
- Publication Type:Journal Article
- Keywords:
breast carcinoma;
LYVE-1;
PROX-1;
lymph node metastasis
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2014;(4):431-433,440
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of LYVE-1 and PROX-1 in human breast carcinoma and the clinical significance of lymphatic vessel density.Methods Immunohistochemistry (SP method)was used to detect the expressions of LYVE-1 and PROX-1 in 80 specimens of breast invasive ductal carcinoma and 35 specimens of breast hyperplasia.Results The density of lymphatic vessels positive for LYVE-1 or PROX-1 was significantly higher in breast carcinoma than in breast hyper-plasia (P<0.01).There was a significant correlation between lymphatic vessel density and lymph node metastasis (P<0.01). A negative correlation was noted between the PROX-1 expression in carcinoma cells and tumor grade (P<0.01)or TNM stage (P < 0.01 ).Conclusion Lymphangiogenesis is increased in breast carcinoma,which is associated with lymph node metastasis.PROX-1 may be involved in tumorigenesis,progression and lymphatic metastasis in breast cancer.
