Function mechanism of leptin on acute pulmonary embolism and lung injury complication in rabbits
10.3760/cma.j.issn.1673-4181.2013.02.011
- VernacularTitle:瘦素在兔急性肺栓塞后并发肺损伤的作用机制
- Author:
Yanmin YAO
;
Xizhu WANG
;
Qiaofeng SONG
;
Yang QIN
;
Huiju LI
;
Tongtong XU
;
Lijie ZHANG
;
Yanhui ZHU
- Publication Type:Journal Article
- Keywords:
Leptin;
Pulmonary embolism;
Lung injury
- From:
International Journal of Biomedical Engineering
2013;(2):108-110,121,后插3
- CountryChina
- Language:Chinese
-
Abstract:
Objective This research aimed to investigate the function mechanism of lung injury after acute pulmonary embolism.Methods 30 healthy New Zealand rabbits were selected and randomly divided into five groups:control group (with venepuncture applied) and model groups including none-saline (NS) control group,exogenos laptin low doses group,medium dose group and high dose group.ELISA was applied to examine the TNF-αand IL-1β in serum.Results TNF-α and IL-1β content in saline group were higher than that in control group,and the results were statistically significant.In medium dose (50 μg/kg) group,TNF-α and IL-1β levels decreased apparently and the results were statistically significant.In low doses (20 μg/kg) group,TNF-α and IL-1β levels decreased,but the results were not statistically significant.In high dose (100 μg/kg) group,TNF-α and IL-1β levels increased on the contrary.Conclusion Suitable dose of leptin will lead the decrease of postoperative levels of TNF-α and IL-1β after acute pulmonary embolism,which thus have protection function to the injured lung.
