Early diagnostic value of combined detection of ischemia-modified albumin and other biochemical markers for acute coronary syndrome
10.3969/j.issn.1008-0074.2013.04
- VernacularTitle:联合测定缺血修饰白蛋白等生化标志物对急性冠脉综合征早期诊断的价值
- Author:
Qi ZHANG
;
Zhiyuan WENG
;
Yahui HUANG
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Diagnosis;
Troponin I;
Ischemia-modified albumin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2013;22(4):321-324
- CountryChina
- Language:English
-
Abstract:
Objective: To explore early diagnostic value of combined detection of ischemia-modified albumin and other biochemical markers for acute coronary syndrome (ACS). Methods: A total of 156 patients, who received treatment within 4h because of chest pain onset, were divided into ACS group (n=112) and non-ischemic chest pain group (NICP group, n=44) according to coronary angiography (CAG). Blood sample was taken within 4h and during 4~8h after chest pain to measure cardiac biochemical markers, including ischemia-modified albumin (IMA), LDH, CK, CK-MB and cardiac troponin I (cTnI), comprehensive analysis was performed by detected results of above biochemical markers and CAG. Results: For diagnosis of ACS, within 4h after onset IMA possessed highest sensitivity (87.50%) and highest accuracy (80.77%), cTnI possessed highest specificity (95.45%); In 4～8h IMA still possessed highest sensitivity (91.07%), cTnI still possessed highest specificity（97.73%）, CK（85.90%），and IMA（85.25%）possessed highest accuracy （both CK and IMA had no significant difference）; According to comprehensive analysis, regardless of within 4h or during 4~8h after chest pain, IMA possessed highest sensitivity and highest accuracy, cTnI possessed highest specificity. Within 4h after chest pain, detection of IMA combined above-mentioned other four indexes increased sensitivity (89.28%), specificity （95.45%） and accuracy （91.02%）to highest level. Conclusion: For diagnosis of ACS, IMA possesses highest sensitivity and highest accuracy, cTnI possesses highest specificity; IMA combined above-mentioned other four indexes may increase sensitivity, specificity and accuracy to highest level.
- Full text:P020130823714216378194.doc
