Correlation between the expression of BAG-1, p53 and platinum-based chemotherapeutic sensitivity in NSCLC

VernacularTitle:BAG-1、p53在非小细胞肺癌中的表达及其与含铂方案化疗敏感性的关系
Author: Qian WU ; Zhitu ZHU ; Minwen HA
Publication Type:Journal Article
Keywords: BAG-1; Genes,p53; Carcinoma,non-small-cell-lung; Platinum; Chemotherapeutic sensitivity
From: Cancer Research and Clinic 2009;21(1):23-25,28
CountryChina
Language:Chinese
Abstract: Objective To detect the expression of BAG-1 and p53 in postoperative patients paraffin section of non-snmll cell lung cancer (NSCLC), and retrospectively analyze the relationships of clinical feature and platinum-based chemotherapeutic sensitivity in NSCLC, to further investigate the resistance mechanism of platinum. Methods The expression of BAG-1 and p53 was measured by immunohistochemistry in paraffin sections of 125 NSCLC postoperative patients. The existence and prognosis were analyzed after follow-up. Results BAG-1 and p53 showed high expression in NSCLC (positive rate 64.8 %, 46.7 %); BAG-1 positive or p53 negative expression had survival advantage(P<0.05); The group of BAG-1, p53 negative expression could benefit from platinum-based chemotherapy (P<0.05). Conclusion Expressions of BAG-1, p53 correlates with platinum-based chemotherapeutic sensitivity, and maybe become new types of clinical prognostic indicators and contribute to individualized treatment options for NSCLC.