Effect of neoadjuvant chemotherapy on R0 resection rate of esophageal carcinoma
10.3760/cma.j.issn.1006-9801.2010.05.003
- VernacularTitle:新辅助化疗提高食管癌手术R0切除率的研究
- Author:
Qingfeng ZHENG
;
Yuan FENG
;
Nan WU
;
Zhendan YAO
;
Yiqiang LIU
;
Yang WANG
;
Jinfeng CHEN
;
Lijian ZHANG
;
Yue YANG
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Neoadjuvant chemotherapy;
R0 resection rate
- From:
Cancer Research and Clinic
2010;22(5):293-296,299
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possibility of increasing R0 resection rate in esophageal carcinoma after neoadjuvant chemotherapy. Methods 30 patients underwent operation after neoadjuvant chemotherapy mainly by paclitaxel combined with cis-platinum, including 18 squamous carcinoma cases. 10 adenocarcinoma cases and 2 small cell carcinoma cases.Results In these 30 patients,the overall effective rate of neoadjuvant chemotherapy is 56.7%(17/30)(CR+PR),R0 resection rate is 100%,and the incidence rate of anastomotic leakage is 3.3%(1/30),without perioperative death.Conclusion The neoadjuvant chemotherapv is significant in improving the R0 resection rate in esophageal carcinoma,and the impact of long-term survival after surgery needs further follow-up.
