Drug-resistance and Aminoglycoside Modifying Enzymes Genes in Acinetobacter baumannii Isolated from ICU
- VernacularTitle:ICU鲍氏不动杆菌分离株耐药性和氨基糖苷修饰酶基因的研究
- Author:
Xiaomao QIAN
;
Haiyong JIN
- Publication Type:Journal Article
- Keywords:
ICU;
Acinetobacter baumannii;
Drug-resistance;
Aminoglycoside modifying enzyme;
Gene detection
- From:
Chinese Journal of Nosocomiology
2009;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the drug-resistance and aminoglycoside modifying enzymes (AME) in Acinetobacter baumannii (ABA) isolated from ICU. METHODS K-B method was conducted to detect the sensitivity to 14 common antibiotics of 291 strains of ABA isolated from 2005 to 2007;PCR was used to detect AME genes of partial bacteria isolated in 2005. RESULTS The drug-resistance rates of 13 kinds of antibiotics were 33.0-91.8%,but cefoperazone/sulbactam was low (12.7%). The rate of amikacin,gentamicin and tobramycin was 41.2%,61.2% and 61.5%. Twenty-three ABA strains were AME gene positive from total 27 ABA strains and the total positive rate was 74.4%.We found 21 strains with aac(3)-Ⅰ (77.8%),23 strains with aac(6′)-Ⅰ (85.2%) and 23 strains with ant(3″)-Ⅰ (85.2%). Two strains were found to have 2 kinds of AME genes,21 strains had 3 kinds of AME genes. The rest of ABA strains had not AME genes. CONCLUSIONS ABA isolated from ICU has strong drug-resistance rate and a high carrier rate,it is a critical area of preventing and controlling hospital infection.
