Gene Regulation by Histone Arginine Modifications
- VernacularTitle:组蛋白精氨酸甲基化修饰对基因转录的调控
- Author:
Zhikui CHENG
;
Qianping GUO
;
Huijian WU
- Publication Type:Journal Article
- Keywords:
histone arginine, methylation, demethylation, transcriptional regulation
- From:
Progress in Biochemistry and Biophysics
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Methylation of histone by protein arginine methyltransferases (PRMTs) plays an important role in gene regulation. PRMT1- and PRMT4-catalyzed methyl-arginine is involved in transcription activation, while PRMT5- and PRMT6-catalyzed methyl-arginine is associated with transcription repression. Histone arginine methylation can be dynamically regulated in vivo, and methyl-arginine is demethylated by "arginine demethylase". Here, the most recent progresses in the methylation studies of histone arginine were summarized.
