Relation of IL-18 and collagen fibre with plaque stability in aorta atherosclerotic lesion
- VernacularTitle:IL-18、胶原纤维和主动脉粥样硬化斑块稳定性的关系
- Author:
Yun LIU
;
Renkuan TANG
;
Jianbo LI
;
Shixiong DENG
- Publication Type:Journal Article
- Keywords:
collagen fibre;
interleukin-18;
atheromatous plaque;
stability
- From:
Basic & Clinical Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate relation of IL-18 and collagen fibre(CF) with plaque stability in aorta atherosclerotic lesion.Methods Morphology and content of CF in rupture of aorta atherosclerotic group(A group),non-rupture of aorta atherosclerotic group(B group) and normal aorta group(C group) were examined by Massion's staining.Expression of IL-18 by was measured immunohistochemical staining among three groups.Results Increasing and arranging turbulence of the CF was found in tunica intima,middle layer and tunica adventitia in A and B groups.Around necrosis of atheromatous plaque,CF significantly increased and arranged turbulence,but the CF decreased or disappeared in necrosis area of atheromatous plaque in A group.The CF significantly increased,arranged turbulence and extended to SMCs in necrosis of atheromatous plaque in B group.Arranging orderliness and absence of disruption of the CF was recorded in C group.Percent age of CF content was significantly different among three groups(P
