Sustained Maintenance of Normal Insulin-like Growth Factor-I during Pregnancy and Successful Delivery in an Acromegalic Patient with Octreotide-LAR(R) Treatment.
10.3803/EnM.2010.25.3.213
- Author:
Soo Kyoung KIM
1
;
Jung Hwa JUNG
;
Jae Hyeon KIM
;
Kyu Yeon HUR
;
Alice Hyun TAN
;
Hee Kyung KIM
;
Ji In LEE
;
Hye Soo CHUNG
;
Kwang Won KIM
Author Information
1. Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kw1234@skku.edu
- Publication Type:Case Report
- Keywords:
Acromegaly;
Insulin-like growth factor-I;
Octreotide;
Pregnancy
- MeSH:
Acromegaly;
Adult;
Female;
Growth Hormone;
Humans;
Infant;
Insulin-Like Growth Factor I;
Male;
Octreotide;
Pregnancy;
Reference Values
- From:Endocrinology and Metabolism
2010;25(3):213-216
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report here on a 34-year-old Korean woman with active acromegaly and who received Octreotide-LAR(R) for 12 months following transsphenoidal pituitary surgery. During Octreotide-LAR(R) treatment, the clinical improvement was paralleled with the decrease of the growth hormone levels to 1.1 ng/mL and the insulin-like growth factor-I (IGF-I) levels to 345.5 ng/mL. Octreotide-LAR(R) was discontinued when the patient was found to be at the 12th week of pregnancy. During pregnancy, the patient experienced clinical well-being and she maintained her IGF-I levels within the normal range for her age-matched despite discontinuation of Octreotide-LAR(R) treatment at early gestation. She delivered a full-term healthy male infant. The serum IGF-I levels of the patient increased progressively increased after delivery. This report describes a successful pregnancy in an acromegalic woman who was exposed to Octreotide-LAR(R) during the early gestational period. She and who showed an unexpected pattern of persistently normal IGF-I levels through the pregnancy despite discontinuation of Octreotide-LAR(R) therapy.
