Expressions and its relationship of vascular interleukin-6 and signal transducer and activator of transcription 3 in patients with giant cell arteritis
- VernacularTitle:巨细胞动脉炎患者血管白介素6与信号传递子和转录激活子3的表达水平及其相关性
- Author:
Shaojuan GU
;
Zhiping HU
- Publication Type:Journal Article
- Keywords:
Giant cell arteritis;
interleukin-6;
signal transducer and activator of transcription 3;
vascular smooth-muscle
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions and its relationship of vascular interleukin-6(IL-6) and signal transducer and activator of transcription 3(STAT3) protein in giant cell arteritis patients.Methods The expressions of IL-6 and STAT3 protein were detected by immunohistochemistry in the temporal artery biopsy specimens of 20 patients with giant cell arteritis and 6 patients with other nerve system diseases(control group).Six indexs related to inflammation in giant cell arteritis patients were recorded.Giant cell arteritis patients were divided into the group that ≥3 positive indexs(7 cases) and the group that ≤2 positive indexs(13 cases).The relationship between expressions of IL-6 and STAT3 protein was analysed.Results Compared with control group[(2.00?0.63)score,(30.73?10.84)cell/H],the expressions of IL-6 and STAT3 protein in temporal artery were significantly increased in giant cell arteritis group[(2.85?0.75)score,(40.71?9.90)cell/H](all P
