Changes and significance of inflammation factors in model rabbit with artherosclerosis induced by hyperhomocysteic acid
- VernacularTitle:高同型半胱氨酸血症兔动脉粥样硬化模型炎性介质的变化及意义
- Author:
Yaqiu JIANG
;
Xiaolin GUO
;
Yan TAN
- Publication Type:Journal Article
- Keywords:
artherosclerosis;
cysteine;
cytokines;
NF-kappa B;
disease model,animal
- From:
Journal of Jilin University(Medicine Edition)
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between hyperhomocysteic acid(HHcy) and artherosclerosis.Methods 20 male rabbits were randomly divided into control and experiment groups(n=10).HHcy models were made by hypodermical injection of DL-methionine for 7 weeks.After 7 weeks homocysteic acid(Hcy),IL-1?,IL-6,and IL-8 in serum of rabbits in two groups were measured by enzyme linked immunosorbent assay(ELISA).And the pathomorphological changes of aorta were observed with HE staining.The number of NF-?B positive cells in the aorta were counted by immunohistochemical method.Results The levels of Hcy,IL-1?,IL-6 and IL-8 in experiment group were higher than those in control group(P
