Effects of ilexonin A on IL-6 and M-CSF following ballon angioplasty in rabbit common carotid artery
- VernacularTitle:毛冬青甲素对兔颈总动脉球囊损伤后炎性因子IL-6和M-CSF的影响
- Author:
Lihua ZHAO
;
Zhangwei LI
;
Chuang YANG
;
Yaqiu JIANG
- Publication Type:Journal Article
- Keywords:
Ilexonin A(IA);
IL-6;
M-CSF;
ballon damage
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of ilexonin A (IA) on IL-6 and M-CSF following ballon angioplasty in rabbit common carotide artery to provide experimental basis for percutaneous coronary interventions. Methods 30 Japanese rabbits were fed with high cholesterol food for 4 weeks. Then they were divided into three groups randomly. Each group had ten rabbits. ①Control group: the incision was sew directly after right carotide artery of the rabbit was seeked. ②Balloon dilation group:the proximal of the carotide artery was cuted,the ballon was delivered and distended,after it was drawn repeatly,the incision was closed. ③IA therapy group: operation was the same to the balloon dilation group,then IA was administered in vein.All of them were fed with high cholesterol diet for 4 weeks and the blood samples were collected 1 d before the operation and 1 d,1,2,4 weeks after the operation. The serum IL-6 and M-CSF levels were determined with radioimmunoassay.The pathological changes of injuried artery were observed. Results ①The IL-6 level in balloon dilation group was higher than that in IA therapy group after the operation (P
