Expression of Her-2/neu,DPC4 and P16 in pancreatic carcinoma and its implication
- VernacularTitle:Her-2/neu、DPC4和P16在胰腺癌中的表达及其意义
- Author:
Zhan HUA
;
Yuanchun ZHANG
;
Zhengeng JIA
;
Zhensheng ZHANG
- Publication Type:Journal Article
- Keywords:
pancreatic carcinoma;
immunohistochemistry;
DPC4;
Her-2/neu;
P16
- From:
Basic & Clinical Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of genes Her-2/neu,DPC4 and P16 in pancreatic carcinomas and to investigate the role of their alterations in tumorigenesis and progression of pancreatic carcinomas.Methods We studied the immunohistochemical markers Her-2/neu,DPC4 and P16 in 34 adenocarcinomas and 12 nonmalignant specimens of the pancreas,and the relationship between DPC4 alterations and various clinicopathological parameters was evaluated.Results There was a significant difference between normal pancreatic tissues and benign pancreatic lesions and primary pancreatic carcinomas for frequency of Her-2/neu expression and loss of P16 expression(P
