Effects of Isoliensinine on Left Ventricular Hypertrophy and Its Possible Mechnism
- VernacularTitle:异莲心碱防止高血压大鼠左室肥厚的可能机制
- Author:
Shu LU
;
Wei SU
;
Hongjun ZHU
- Publication Type:Journal Article
- Keywords:
Isoliensinine;
Essential hypertension;
Left ventricular hypertrophy myocardial;
Sarco/Endoplasmic reticulum Ca~(2+)-ATP_(ase)
- From:
Chinese Journal of Hypertension
2007;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Background Isoliensinine(IL) is a kind monomer alkaloid of double benzyl group quinoline separated from Plumula nelumbinis,which has been speculated to have antiarrhythmic effect,Ca~(2+) and?1-receptor blockade, and reversal the left ventricular hypertrophy(LVH).It has been reported the activity of Sarco/Endoplasmic reticulum Ca~(2+)-ATP_(ase)(SERCA) in essential hypertention(EH)/LVH patients was lower than that of healthy people. Objective To investigate the effects of Isoliensinine on left ventricular hypertrophy and activity of SERCA in 2 kidney 1 clamp(2K1C) hypertensive rats.Methods 2K1C hypertensive rats were randomly received Isoliensinine (RHR-IL,5 mg/kg per day p.o,n=16) or placebo.Blood pressure,left ventricle mass index(LVMI) and the activity of myocardial SERCA were measured after 10 weeks treatment.Six untreated SD rats were served as control. Results Isoliensinine decreased BP and LV/BM ratio(IL:136.4?14.6 vs control:189.8?4.4 mm Hg,P
