Correlation of PARP expression with P-selectin and ICAM-1 expression in colorectal carcinoma
- VernacularTitle:大肠癌PARP表达与P-selectin和ICAM-1表达的相关性
- Author:
Lanxiang HAO
;
Yalan WANG
- Publication Type:Journal Article
- Keywords:
PARP;
colorectal carcinoma;
metastasis;
immunofluorescence double staining;
immunohistochemistry
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of PARP with the metastasis of colorectal carcinoma.Methods Poly(ADP-ribose) polymerase activity was tested by detecting poly-ADP ribose.Immunohistochemical SP was used to detect the expression of PAR,P-selectin and ICAM-1 in colorectal carcinoma and control colorectal mucosa.The co-expression of PAR with P-selectin and ICAM-1 was investigated by immunofluorescence staining in colorectal carcinoma and control colorectal mucosa.Results The expression of PAR,P-selectin and ICAM-1 was significantly higher in colorectal carcinoma than that in the control colorectal mucosa((P
