Study on relationship between polymorphism of TNF-?and IgA nephropathy of Han nationality Chinese in inner Mongolia Autonomous Region
- VernacularTitle:内蒙古地区汉族人群TNF?基因多态性与IgA肾病的相关性
- Author:
Cheng WANG
;
Caili WANG
;
Lijun GAO
;
Tianlin JU
;
Wenbin QIN
- Publication Type:Journal Article
- Keywords:
tumor necrosis factor;
?gene polymorphism;
IgA nephropathy
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of tumor necrosis factor beta (TNF-?) polymorphism with human IgA nephropathy of Chinese Han nationality in Inner Mongolia Autonomous Region. Methods The A→G single base mutation polymorphism in TNF-?1096 locus were analyzed among 80 normal controls and 79 IgA nephropathy patients by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The genotype frequencies of TNF?* 1/1 and TNF?* 2/2 in IgA nephropathy patients were significantly higher than that in normal controls (x1/12=5.58,P
