Effects of tert-butyl hydroperoxide and hypoxia in transient ischemia-like attack in mice
- VernacularTitle:叔丁基氢过氧化物及低氧在小鼠短暂性脑缺血样发作中的作用
- Author:
Hongli HUANG
;
Baojian CHEN
;
Yongping WU
- Publication Type:Journal Article
- Keywords:
tert-butyl hydroperoxide;
hypoxia;
transient ischemia-like attack;
hemorheology
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects and relationship of tert-butyl hydroperoxide (t-BHP) and hypoxia in transient ischemia-like attack (TIA-like) in Kunming mice.Methods Fifty-six mice were randomly divided into normal saline group (group A), t-BHP group (group B), t-BHP plus hypoxia group (group C) and model group (group D). Fourteen mice in group D were injected t-BHP (0.11 mol/L, 10 ml/kg) through tail vein with an interval of 24 hrs to induce TIA-like attack. The average time of TIA-like was ( 3.7? 1.1) days, and this time was used as experimental evidence to collect blood sample in other groups. Hemorheological indexes before TIA-like attack were observed in different experimental conditions.Results Compared with group A, the whole blood viscosity at shear rate 100S-1, 1S-1 and Fibrinogen were significantly increased in group B and group C (all P
