An association analysis of apolipoprotein E genotype and Alzheimer's disease in old population in Urumqi
- VernacularTitle:乌鲁木齐市老年人群中载脂蛋白E基因与Alzheimer病的相关分析
- Author:
Jiang HE
;
Changwen ZHOU
;
Junhao GUI
- Publication Type:Journal Article
- Keywords:
Alzheimer disease Apolipoprotein E Polymorphism Genotype Allele
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the correlation of apolipoprotein E genotype and Alzheimer's disease(AD) in old population in Urumqi.Methods The polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) techniques were used to detect the distribution of genotype, gene frequency of ApoE alleles in 60 cases with sporadic AD and 90 normals as control.Results The frequency of ApoE?2, ApoE?3, ApoE?4 was 6.67%, 75.83% and 17.50% respectively in AD group, while in control group, it was 13.33%, 79.45% and 7.22% respectively. The frequency of ApoE?4 allele in AD group was higher than that in control group( P
