The effect of the expression and influence of MMP-9 on prognosisof nasal polyps

VernacularTitle:基质金属蛋白酶9和嗜酸粒细胞在鼻息肉组织的表达及其对预后的影响
Author: Jiangbo CHEN ; Tiansheng WANG ; Hong SUN
Publication Type:Journal Article
Keywords: nasal polyps; metrix metalloproteinase 9; eosinophils; prognosis
From: Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2009;(18):840-842,845
CountryChina
Language:Chinese
Abstract: Objective:To study the expression of MMP-9 and eosinophils in nasal polyps and its influence on the prognosis. Method:Study the expression of MMP-9 and EOS on the tissue of nasal polyps of patients who were cured or recurrent and normal nasal mucosa(NM) by immunohistochemisty and HE staining. Result:In the patients of recurrent group (Group B) , the expression of MMP-9 was much stronger than that of good prognosis group (Group A) and NM. The MMP-9 was stronger in the eosinophil nasal polyps than that of non-eosinophil groups. The percentage of EOS in Group A was 16.67% , while 62.50% in the Group B. Conclusion:The stronger expres-sion of MMP-9 on Group B and eosinophil group indicated that MMP-9 might affect the prognosis of nasal polyps through inducing the number of EOS in the mucosa. MMP-9 may be one of the risk factors for the relapse of nasal polyps.