Infections after lung transplantation: time of occurrence, sites, and microbiologic etiologies.
10.3904/kjim.2015.30.4.506
- Author:
Ji Hyun YUN
1
;
Sang Oh LEE
;
Kyung Wook JO
;
Se Hoon CHOI
;
Jina LEE
;
Eun Jin CHAE
;
Kyung Hyun DO
;
Dae Kee CHOI
;
In Cheol CHOI
;
Sang Bum HONG
;
Tae Sun SHIM
;
Hyeong Ryul KIM
;
Dong Kwan KIM
;
Seung Il PARK
Author Information
1. Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. soleemd@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Lung transplantation;
Infection;
Epidemiology
- MeSH:
Adult;
Bacterial Infections/diagnosis/*microbiology/mortality;
Catheter-Related Infections/microbiology/virology;
Cytomegalovirus Infections/virology;
Female;
Heart-Lung Transplantation/*adverse effects/mortality;
Humans;
Kaplan-Meier Estimate;
Lung Transplantation/*adverse effects/mortality;
Male;
Medical Records;
Middle Aged;
Mycoses/diagnosis/*microbiology/mortality;
Pneumonia, Bacterial/microbiology;
Registries;
Republic of Korea/epidemiology;
Risk Factors;
Time Factors;
Treatment Outcome;
Virus Diseases/diagnosis/mortality/*virology
- From:The Korean Journal of Internal Medicine
2015;30(4):506-514
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Infections are major causes of both early and late death after lung transplantation (LT). The development of prophylaxis strategies has altered the epidemiology of post-LT infections; however, recent epidemiological data are limited. We evaluated infections after LT at our institution by time of occurrence, site of infections, and microbiologic etiologies. METHODS: All consecutive patients undergoing lung or heart-lung transplantation between October 2008 and August 2014 at our institution were enrolled. Cases of infections after LT were initially identified from the prospective registry database, which was followed by a detailed review of the patients' medical records. RESULTS: A total of 108 episodes of post-LT infections (56 bacterial, 43 viral, and nine fungal infections) were observed in 34 LT recipients. Within 1 month after LT, the most common bacterial infections were catheter-related bloodstream infections (42%). Pneumonia was the most common site of bacterial infection in the 2- to 6-month period (28%) and after 6 months (47%). Cytomegalovirus was the most common viral infection within 1 month (75%) and in the 2- to 6-month period (80%). Respiratory viruses were the most common viruses after 6 months (48%). Catheter-related candidemia was the most common fungal infection. Invasive pulmonary aspergillosis developed after 6 months. Survival rates at the first and third years were 79% and 73%, respectively. CONCLUSIONS: Although this study was performed in a single center, we provide valuable and recent detailed epidemiology data for post-LT infections. A further multicenter study is required to properly evaluate the epidemiology of post-LT infections in Korea.
