Clinical Manifestations of Recurrent Parotid Pleomorphic Adenoma.
- Author:
Myung Whan SUH
1
;
J Hun HAH
;
Seong Keun KWON
;
Young Ho JUNG
;
Tack Kyun KWON
;
Kwang Hyun KIM
;
Myung Whun SUNG
Author Information
- Publication Type:Original Article
- Keywords: Pleomorphic adenoma; Parotid glancl; Recurrence; Risk factor
- MeSH: Adenoma, Pleomorphic; Humans; Medical Records; Recurrence; Retrospective Studies; Risk Factors
- From:Clinical and Experimental Otorhinolaryngology 2009;2(4):193-197
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVES: This study was undertaken to confirm the clinical characteristics of recurrent pleomorphic adenoma (RPA), and to identify those factors that affect the development of malignant transformation (MT) from RPA. METHODS: The medical records of 270 patients, who were operated upon for parotid PA, were retrospectively reviewed. The pathologic specimens of a selected series of 23 patients were reviewed for histologic subtype and microscopic multi-nodularity. RESULTS: Mean age of initial operation in RPA without MT (RPA(-MT)) group was significantly lower than that of primary PA group. Mean age of the revision operation in RPA with MT (RPA(+MT)) group was significantly greater than that of RPA(-MT) group. Mean interval from operation to recurrence shortened after each revision operation. The risk of MT and additional recurrence increased significantly with recurrence. In RPA(-MT) group tumor recurrence occurred in 21.4% of patients despite a clear resection margin. CONCLUSION: The risk factors for MT may be an age of over 45 yr and multiple recurrences. However, younger patients are more at risk of recurrence. A clear resection margin cannot guarantee a cure in RPA, and it seems that parotid pleomorphic adenomas slowly gain malignant characteristics after repeated recurrences.
