A comparison of rhPTH(1-34) and calcitonin therapy for post-menopausal women with osteoporosis
- VernacularTitle:重组人甲状旁腺素(1-34)与降钙素治疗绝经后骨质疏松临床观察
- Author:
Yunfan ZHOU
- Publication Type:Journal Article
- Keywords:
rhPTH(1-34);
Calcitonin;
Osteoporosis;
Bone mineral density
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the therapeutic effects of recombinant human parathyroid hormone[rhPTH(1-34)]and calcitonin on post-menopausal women with osteoporosis.Methods:56 postmenopausal women with osteoporosis were randomly divided in to PTH (n=30)and CT(n=26)groups.The patients in PTH group were treated with rhPTH(1-34)20?g/d by subcutaneous injection,and those in CT group were treated with calcitonin 20 IU/week by intramuscular injection.All patients were given oral calcium(Ca 600 mg+Vit D3 125 U,QD).All the treatments lasted for six months.Lumbar spine(L_(2～4))bone mineral density(BMD),T value,serum calcium,serum phosphate and serum alkline phosphatase were measured in two groups before and after treatment.Results:In two groups BMD was remarkably increased after treatment[PTH:(0.74?0.09 vs 0.76?0.08)g/cm~2;CT:(0.74?0.09 vs 0.76?0.09)g/cm~2,P
