Effect of Wenxiao Granule on the Expression of MCP-1 and TNF-? in Experimental Atherosclerosis Rabbits
- VernacularTitle:稳消颗粒对兔实验性动脉粥样硬化单核细胞趋化蛋白-1及肿瘤坏死因子?表达的影响
- Author:
Qingping HUO
;
Fang LIANG
;
Jinpu LI
- Publication Type:Journal Article
- Keywords:
Wenxiao Granule;
atherosclerosis;
MCP-1;
TNF-a;
animal model
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Wenxiao Granule on the expression of MCP-1 and TNF-? in experimental atherosclerosis rabbit, and explore its mechanism in treating atherosclerosis. Methods Thirty-six New Zealand rabbits were randomized to four groups: control group, Wenxiao granule group, Simvastatin group. They were fed a high-fat diet except normal group until the mature atherosclerotic plaques formed. The rabbits in two drug-treated groups were treated with respective drug for 8 weeks. All rabbits were sacrificed. The morphology and composition of atherosclerotic plaques in aortic roots were examined. The expression of MCP-1 and TNF-? were determined by immunohistochemical staining. Results The expression of MCP-1 and TNF-? in plaque of Wenxiao Granule group and simvastatin group were significantly dereased compared with the model group (P 0.05). Conclusion Wenxiao Granule can inhibit the expression of MCP-1 and TNF-?, which may stabilize plaque of atherosclerosis.
