Antioxidative effect of xanthones in Vitro
- VernacularTitle:酮体外抗氧化作用研究
- Author:
Yuanyuan ZHANG
;
Di GUAN
;
Qinglan XIE
;
Dehe YU
- Publication Type:Journal Article
- Keywords:
xanthone;
Swertia macrosperma;
lipid peroxidation;
hydroxyl free radical
- From:
Chinese Traditional Patent Medicine
1992;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the antioxidative effect of three kinds of xanthone:methylswertianin(MET), bellidifodin(BEL) and decussatin (DEC) extracted from Swertia macrosperma C.B. clark. METHODS: Hydroxy radical was generated from H_2O_2 and VC-Fe~ 2+ system; MDA contents in liver homogenate and mitochondria were measured by thiobabituric acid assay; the hemolysis of RBC and the swelling extent of mitochondria were detected by spectrophotometric methods. RESULTS: Xanthones could inhibit the generation of MDA, the hemolysis of RBC, and the swelling of mitochondria. The inhibitory effect of BEL was stronger than that of MET and DEC. CONCLUSION: Xanthones possess a good antioxidant activity.
